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Program

Day One Thursday, November 13

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8:00-8:55am      Breakfast

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8:55-9:00am      Opening Remarks, Chris Dulla

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9:00-10:40am    Session 1: Identifying circuit dysfunction in epilepsy

  • Discussion Leader: John Huguenard, Stanford (9-9:10)

  • Speakers:

    • Doug Coulter, Penn (9:10-9:40)

      • Conceptual and Technical Advances Driving Progress across 40 Years of Epilepsy Bench Research​

    • Joanna Mattis, U Michigan (9:40-10:10)

      • Subcortical Neuromodulatory Networks In a Dravet Syndrome Model​

    • Mark Beenhakker, U of Virginia (10:10-10:40)

      • Resolving Global Neuronal Synchrony in Childhood Absence Epilepsy

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​10:40-11:00am    Coffee Break & Virtual Poster (Clare Timbie)

 

11:00-12:40pm    Session 2:  Abnormal circuit development in epilepsy

  • Discussion Leader: Dr. Juliet Knowles, Stanford (11:00-11:10)

  • Speakers: 

    • Gabrielle Devienne, Stanford (11:10-11:40)

      • Prefrontal Cortex Maturation in Typical and Neurodevelopmental Conditions​

    • Xiaoming Jin, Indiana U​ (11:40-12:10)

      •  Homeostatic Plasticity in the Development and Treatment of Posttraumatic Epilepsy and Neuropathic Pain​

    • Linda Overstreet-Wadiche, U Alabama @ Birmingham (12:10-12:40)

      • Temporal Pattern Decorrelation by Adult-Born Neurons​

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12:40-2:00pm    Lunch

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2:00-5:00pm      Rigor in Science & Trainee Presentations

  • Discussion Leader: John Huguenard, Stanford

  • Speakers, Session #1 

    • Anita Bandrowski, Founder and CEO at SciCrunch (2:00-2:15)

      • Should Electrophysiologists Care About Rigor and Transparency?

    • John Huguenard, Stanford (2:15 -2:30)

      • ​Is There a Good Alternative to CNS Journals for Publication of High Value Research? The eLife Model

    • Yuliya Voskobiynyk, UCSF (2:30-2:43)

      • Sex-Dependent Thalamocortical Circuit Hyperexcitability Mediates Absence Epilepsy in Scn2a Haploinsufficiency​

    • Mia Sherer, Penn (2:43-2:56)

      • ​A Novel Mouse Model of SCN3A-Related Neurodevelopmental Disorder

    • Katie Salvati, UCSF (2:56-3:09)

      • Examining Sensory Perception in Scn2a Loss-of-Function​

    • Brittney Boublil, UC Irvine (3:09-3:22)

      • Hippocampal Representation of a New Environment in a Rodent Model of Temporal Lobe Epilepsy​

    • Yotam Eldar, Co-Founder & CEO at Modulight.Bio (3:22-3:35)

      • Work in Optogenetic Inhibition of Seizures in a mTLE Model​

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  • Coffee Break (3:35-3:55)
     
  • Speakers, Session #2
    • ​Belen Perez, Stanford (3:55-4:08)
      • ​Anterior Callosal Myelin Plasticity Promotes EpilepsyProgression​

    • ​Justin Yi, UC Irvine (4:08-4:21)

      • Hippocampal Sharp Wave Ripples Are Desynchronized Across Hemispheres in a Model of Focal Epilepsy

    • Sung-Soo Jang, Stanford (4:21-4:34)

      • Reticular Thalamus Excitability Imbalance Drives ASD-Related Behaviors​

    • Olive Tambou, UCSF (4:34-4:47)

      • Mediodorsal Thalamic Stroke Induces Prefrontal Cortex Hyperexcitability: Implications for Post-Stroke Epileptogenesis and Cognitive Dysfunction

    • Gil Vantomme, Stanford (4:47-5:00)

      • Beyond Seizure Control: Identifying Deficits in Cognitive Networks in Absence Epilepsy​​​

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​6:00pm                 Dinner

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Day Two Friday, November 14

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8:00-9:00am      Breakfast

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9:00-10:40am    Session 3: Ion channel dysfunction in epilepsy

  • Discussion Leader: Alberto Bacci (9-9:10)

  • Speakers:

    • Jeanne Paz, UCSF (9:10-9:40)

      •  A Dual Inhibitory Network in the Thalamic Reticular Nucleus Delineated by Pallidal and Intra-Reticular Inhibition

    • Chris Makinson, Columbia (9:40-10:10)

      • Local thalamic interneurons: A new sheriff in relay town​

    • Ethan Goldberg, Penn (10:10-10:40)

      • Ionic Mechanisms Underlying Temperature-Sensitive Seizures​

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10:40-11:00am   Coffee Break & Virtual Poster (Erica Nebet)

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11:00-12:40pm   Session 4: Glial signaling and epileptogenesis

  • Discussion Leader: Ethan Goldberg, Penn (11:00-11:10)

  • Speakers:

    • Juliet Knowles, Stanford (11:10-11:40)

      • Maladaptive Myelination Promotes Generalized Epilepsy Progression​

    • Annalisa Scimemi, SUNY Albany (11:40-12:10)

      • Small Things Make Big Differences: Why Regulating Glutamate Escape Transforms Hippocampal Activity​

    • Chris Dulla, Tufts (12:10-12:40)

      • ​Why Does Loss of GABA Transport Cause Epilepsy?​​

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12:40-2:00pm     Lunch

 

2:00-3:40pm      Session 5: Mechanisms of co-morbidities in epilepsy

  • Discussion Leader: Brielle Ferguson (2:00-2:10)

  • Speakers:

    • Vikaas Sohal, UCSF (2:10-2:40)

      • Inhibitory Circuit Dysfunction and Aberrant Synchronization in Neuropsychiatric Disease​

    • Laura Ewell, UC Irvine (2:40-3:10)

      • Interictal Spikes - Mechanisms and Impacts On Memory​

    • Trent Anderson, U Arizona (3:10-3:40)

      • Head-Banging Neurons: Circuits Driving Post-Traumatic Headache​

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3:40-4:00pm     Coffee Break & Virtual Poster (Audrey Magsig)

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4:00-5:40pm     Session 6: New models of circuit dysfunction

  • Discussion Leader: Kevin Staley, Harvard (4:00-4:10)

  • Speakers:

    • Jacob Hull, Stanford (4:10-4:40)

      • ​Modeling Complexity: Interpretable Machine Learning Identifies a Multiregional Absence Seizure Mechanism

    • Omer Revah, Hebrew U of Jerusalem (4:40-5:10)

      • From Organoids to Circuits: Novel Cortical Models for Understanding Neurodevelopmental Disorders​

    • Qian-Quan Sun, U Wyoming (5:10-5:40)

      • ​The Role of Nested Oscillations In Epileptogenesis and Seizure Progression In Two Mouse Models

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5:40-5:45pm      Closing Remarks, Mark Beenhakker

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